Korenkov, O. V., 2017.

Healing of experimental femoral defects in rats after implantation of collagen-calcium phosphate biocomposites.

Bulg. J. Vet. Med., 20, No 2, 151–160.

The aim of this study was to investigate the healing process of experimental defects of the femoral shaft diaphysis of rats after implantation of osteoplastic material Collapan into its cavity. In experimental animals, a perforated defect with diameter of 2.5 mm was created in the medullary canal of the femoral shaft and filled with osteoplastic material Collapan. In control rats, the defect was left unfilled. The bone fragments were examined on the 15^th and 30^th day by light microscopy morphometry and scanning electron microscopy. It was found that application of osteoplastic material Collapan in the femoral diaphysis defect optimised reparative osteogenesis, showed high biocompatibility, osteoconductive properties, resorption ability and good integration with tissue-specific structures of the regenerate.

Key words: bone, Collapan, rats, reparative osteogenesis