Abdelnaby, E. A. & A. M. Abo El-Maaty, 2017.
Luteal blood flow and growth in correlation to circulating angiogenic hormones
after spontaneous ovulation in mares.
Bulg. J. Vet. Med., 20, No 2, 97–109.
For evaluating corpus luteum (CL) function, blood flow, circulating nitric oxide
(NO), estradiol (E2), progesterone, leptin and insulin like growth factor-I
(IGF-1) concentrations were measured for 11 days that were equally divided into
early and mid-luteal phases. Five mares underwent blood sam-pling and rectal
Doppler ultrasound examination for 18 days for two estrous cycles. CL diameter,
circumference, area and volume increased till day 11. Both blood flow blue area
and power area in-creased from day 1 to 11 but colour blood flow red area
declined till day 11. NO concentration in-creased till day 5 then decreased till
day 11. Leptin concentrations declined from day 1 to 11. Power blood flow area
and colour blood flow blue area exhibited a significant negative correlation
with E2 (r= –0.79; –0.75), leptin (r= –0.73; –0.51), and IGF-1 (r= –0.56;
–0.60), but had a positive one with progesterone (r=0.47; 0.52). Days after
ovulation and luteal phase affected significantly luteal blood flow and hormone
concentrations. The relatively high E2, leptin, IGF-1 and NO during growth
com-pared to static phase indicated a role enhancing angiogenesis and early CL
development.
Key words: Doppler, IGF-1, leptin, luteal
vascular perfusion, mare, nitric oxide