Lashev, L., 2017.

Allometric analysis of the pharmacokinetics of four cephalosporin antibiotics in mammals.

Bulg. J. Vet. Med., 20, No 1, 27–37.

Allometric analysis of the total body clearance (Cl_B), steady-state volume of distribution (V_ss) and elimination half-life (t_1/2b) was performed for cephalexin, cefepime, cefquinone and ceftriaxone based on literature data in mammalian species. Values of Cl_B and V_ss show allometric dependence on body weight, while values of t_1/2b could not be predicted correctly after scaling toward body weight. The equations based on the calculations which could be used for estimation of the respective pharmacokinetic parameters are as follows: Cephalexin: Cl_B=0.20W^1.05; Vss=0.32W^0.98; Cefepime: t_1/2β =1.03W^0.16; Cl_B=0.35W^0.68; V_ss=0.133W^0.99; Ceftriaxone: t_1/2β=0.83W^0.13; Cl_B=0.76W^0.73; V_ss=0.82W^0.79; Cefquinome: Cl_B=0.22W^0.875; V_ss=0.298W^0.975.

Key words: allometric scaling, cefepime, cefquinome, ceftriaxone, cephalexin, pharmacokinetics